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Metabolic Endotoxemia and Heart Disease

Written by Acacia Young , Director of Scientific Affairs at Microbiome Labs Among non-communicable diseases, metabolic endotoxemia is the leading cause of morbidity and mortality worldwide. Metabolic endotoxemia is a condition that stems from intestinal dysbiosis and a breakdown of intestinal barrier function. This condition triggers an innate immune response that results in sub-clinical, persistent, and low-grade inflammation due to …

Metabolic Endotoxemia

A Driving force Behind Chronic Illness Written by Kiran Krishnan, Microbiologist, Clinical Researcher and CSO of Microbiome Labs, USA Metabolic endotoxemia is a condition that is estimated to affect approximately 33% of the western population. The condition is characterized by increased serum endotoxin (typically lipopolysaccharide) concentration during the first five hours of the post-prandial period following consumption of a meal. …

Immunity and infectious disease – the central role of the microbiome

The Human Microbiome Project has discovered that each microbiome contains up to 3.3 million unique protein-encoding genes.  This burgeoning area of research continues to highlight the importance of the microbiome and the extent of its reach.  One continuing area of study is looking at its relationship to our immunity. It is now understood that a balanced microbiome is central to …

The gut-lung axis

The last few decades of research have seen an acceleration of understanding into the numerous microbial communities that reside on and within us.  These can be found all over the skin, in the mouth, the airways, the vagina, with the largest and most significant residing in the gastrointestinal tract.  This gut microbiome assimilates many dietary nutrients indigestible by the human …

The power of the Bacillus subtilis HU58 spore

The Bacillus subtilis HU58 strain was first isolated from a healthy human microbiome by spore expert Professor Simon Cutting at Royal Holloway University (which explains the HU in the name).  Bacillus subtilis spores have been shown in a 2009 study to have “the ability to sporulate anaerobically, to secrete antimicrobials and to form (protective) biofilms.” (2009, Hong et al). The …

Novel Strategies for dealing with a Candida Overgrowth

Candida albicans is one of the fungi found in the microbiomes that exist all over the hu- man body, coexisting alongside other fungi, bacteria and viruses. Diversity and balance are the hallmarks of a healthy microbiome, which enables it to keep any opportunistic species in check, but when either of these qualities is lost, Candida, and in particular, Candida albicans, can start to overgrow …

Prebiotic Considerations

The current scientific consensus definition of a prebiotic is, “a substrate that is selectively utilised by host microorganisms conferring a health benefit,” which was developed by a panel of experts in microbiology, nutrition and clinical research in 2016 under the umbrella of the International Scientific Association for Probiotics and Prebiotics (ISCAPP).   The first mention of prebiotics was, however, in …