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MegaSporeBiotic
PLUS
With Antioxidants

100% SPORE-BASED PROBIOTIc
PLUS ANTIOxIDANTS
4 billion cfu

MegaSporeBiotic™ PLUS is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ PLUS boasts a 2-year shelf-life, does not require refrigeration, and maintains efficacy during antibiotic therapy.

How to buy

Practitioner
PATIENT

MegaMucosa 180 Capsules

MUSCOSAL SUPPORT

MegaMucosa is the first complete mucosal support supplement of its kind, formulated to REBUILD a healthy mucosal barrier. MegaMucosa also contains a blend of five specifically selected amino acids and bioflavonoids clinically shown to support microbial diversity and alleviate barrier dysfunction, otherwise known as leaky gut.

How to buy

  • Practitioner
  • Patient
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At a Glance

The first complete mucosal support supplement of its kind

MegaMucosa is the first complete mucosal support supplement of its kind, formulated to REBUILD a healthy mucosal barrier. MegaMucosa contains five specifically selected amino acids and bioflavoniods, a state-of-the-art flavobiotic, clinically shown to support microbial diversity and alleviate barrier dysfunction, otherwise known as leaky gut.

The mucosal system is a very important part of the human immune system. Not many people think of mucus as being protective, but it is the main interface between the human body and the outside world. The mucosal system contains 150 times more surface area than skin, which makes it one of the most important immune barriers. The health of the mucosa determines how the body interacts with antigens; therefore, the integrity of the intestinal mucosa can dictate overall immune function.

What does it do?

There are five key amino acids that play an important role in the production and protection of the intestinal mucosa: L-proline, L-serine, L-cysteine, L-threonine, and L-glutamine. These five amino acids have been shown to increase mucin2 production and stimulate mucin synthesis in the colon, resulting in a thicker and healthier mucosal barrier.

MicrobiomeX® is a natural citrus extract rich in polyphenols that supports digestive health and immunity by increasing microbial diversity in the gut and maintaining healthy gut barrier function. A clinical study using 500mg of citrus fruit extract found a significant increase in short-chain fatty acid (SCFA) composition, suggesting that these polyphenols may help modulate the microbial composition in the gut.

Ingredients

Dosing Instructions

Take 6 capsules daily with or without food, or as directed by your healthcare practitioner. The capsules can be opened into cold water or liquid of your choice.

Research

Dlugosz A, et al.

Increased serum levels of lipopolysaccharide and anti-flagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 2015;27(12):1747-54.

Fritscher-Ravens A, et al.

Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology. 2014;147(5):1012-20.

Romier B, Schneider YJ, Larondelle Y, et al.

Dietary polyphenols can modulate the intestinal inflammatory response. Nutr Rev. 2009;67(7):363-78.

Jason VS, Burnett BP.

Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humans. Nutrition Journal. 2015;14:22.

Faure M, Mettraux C, Moennoz D.

Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006;136(6):1558-64.

König J, et al.

Human Intestinal Barrier Function in Health and Disease. Clin Transl Gastroenterol. 2016 Oct 20;7(10):e196. doi: 10.1038/ctg.2016.54.
  • Practitioner
  • Patient
  • Customer
A valid Practitioner account is required for direct purchases from our website. Let’s get you registered!
Practitioner Locator Coming Soon.  In the meantime, please contact us for your nearest practitioner.  If you already have a practitioner and they have referred you to this site, please register as a patient here.

Buy Now

Registered practitioners can login here to purchase at practitioner price.

At a Glance

The 1st probiotic to PROTECT its human host

MegaSporeBiotic PLUS is a probiotic blend of 4 Bacillus spores that have been clinically shown to maintain healthy gut barrier function and overall immunity. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favourable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut instead of reseeding with probiotic strains that cannot survive digestion or colonize the gut. MegaSporeBiotic PLUS has quickly become a household favourite among health practitioners and consumers alike.

Ingredients

Dosing Instructions

Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.

If 1 capsule every other day is too strong, try starting with 1/2 capsules or even 1/4 capsule in some cases. Possible symptoms may include abdominal cramping, loose stools, and changes in bowel movements. Though these symptoms may be uncomfortable, they are a sign that the product is working! Symptoms should resolve within 2-3 days.

Week 1
1 capsule every other day
Week 2
1 capsule daily
Week 3+
2 capsules daily

Research

McFarlin BK, Henning AL, Carbajal KM.

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers. World J Gastrointest Pathophysiol. 2017 Aug 15; 8(3): 117–126.

Rhee KJ, Sethupathi P, Driks A, et al.

Role of commensal bacteria in development of gut-associated lymphoid tissue and preimmune antibody repertoire. J Immunol. 2004;172(2):1118-24.

De Punder K, Pruimboom L.

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol. 2015;15(6):223.

Gong Y, Li H, Li Y.

Effects of Bacillus subtilis on epithelial tight junctions of mice with inflammatory bowel disease. J Interferon Cytokine Res. 2016;36(2).

Samanya M, Yamauchi K.

Histological alterations of intestinal villi in chickens fed dried Bacillus subtilis var. natto. Comp Biochem Physiol A Mol Integr Physiol. 2002;133(1):95-104.

Tam NKM, Uyen NQ, Hong HA, et al.

The Intestinal Life Cycle of Bacillus subtilis and Close Relatives. Journal of Bacteriology. 2006;188(7):2692-2700.

“Survival of Probiotics in Simulated Gastric Fluid.”

Food Science Center Report. Silliker Labs. RPN 16663. August 24, 2013.

Gibson GR, Rouzaud G, Brostoff J, et al.

An evaluation of probiotic effects in the human gut: microbial aspects. Final Technical report. FSA project ref G01022.

Lefevre M, Racedo SM, Ripert G, et al.

Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immun Aging. 2015;12:24.

Serra CR, Earl AM, Barbosa TM, et al.

Sporulation during Growth in a Gut Isolate of Bacillus subtilis. J Bacteriol. 2014;196(23):4184-4196.

Hong HA, Khaneja R, Tam NMK, et al.

Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009;160(2):134-143.

Mandel DR, Eichas K, Holmes J.

Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010;10:1.

Marseglia GL, Tosca M, Cirillo I, et al.

Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study. Ther Clin Risk Manag. 2007;3(1):13-7.

Urdaci MC, Bressollier P, Pinchuk I, et al.

Bacillus clausii probiotic strains: antimicrobial and immunomodulatory activities. J Clin Gastroenterol. 2004;38(6 Suppl):S86-90.

Nista EC, Candelli M, Cremonini F, et al.

Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial. Aliment Pharmacol Ther. 2004 Nov;20(10):1181-8.

Gabrielli M, Lauritano EC, Scarpellini E, et al.

Bacillus clausii as a Treatment of Small Intestinal Bacterial Overgrowth. Am J Gastroenterol. 2009;104(5):1327-8.

Di Caro S, Tao H, Grillo A, et al.

Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis. Eur J Gastroenterol Hepatol. 2005;17(9):951-60.

Ciprandi G, Tosca MA, Milanese M, et al.

Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: A pilot study. Pediatr Allergy Immunol. 2004;15(2):148-51.

Casula G, Cutting SM.

Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract. App Environ Microb. 2002;68(5):2344-2352.
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